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KMID : 0378019700130030055
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New Medical Journal
1970 Volume.13 No. 3 p.55 ~ p.65
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An Experimental Study on Bladder Reconstruction
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Abstract
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One hundred and ten rats weighing 100 gm. or more were used. These animals were divided into two study groups. The frist consisted of 80 rats and this group was used to follow up the process of bladder regeneration. The second consisted of 30 rats and in this group polyethylene tube (I. D. .023´XO.D. .035") was placed in the space after subtotal cystectomy through the urethra, and the tube was sutured to the urethra with 4-0 silk to investigate whether the urinary retention is necessary for the bladder regeneration. Anesthesia was accomplished by intraperitoneal and through a subumbilical median incision the bladder was exposed transperitoneally and subtotal cystectomy was done saving the trigone and ureteral orifices. To prevent the urinary leakage the edge of remnant bladder was closed with 0 chromic catgut.
In the first group, 10 rats each were sacrificed at intevals of one week after initial operation for 8 weeks. There was complete ´restoration of what appeared to be normal bladder capacity at the end of 8 weeks. The regenerated bladder was a definite thick-walled pouch lined with normal epithelium and many capillaries.
In the secound group, 30 rats were sacrificed after the intial operation: 6 each at the 4th, 5th, 6th, 7th and 8th week. At the end of 8 weeks regeneration of the bladder was markedly inhibited as compared with the first group.
The most inhibitory factor in bladder regeneration is the wound infection.
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KEYWORD
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